Tunable biohybrid hydrogels from coacervation of hyaluronic acid and PEO‐based block copolymers
نویسندگان
چکیده
منابع مشابه
Solid phase synthesis of biohybrid block copolymers.
A new versatile route to synthesise biohybrid block copolymers is presented in which an amine terminated polymer is attached to an aldehyde functionalised resin, from which in subsequent steps the desired peptide can be grown using standard procedures.
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The synthesis and self-assembly behavior of biohybrid ABC triblock copolymers consisting of a synthetic diblock, polystyrene-b-polyethylene glycol (PSm-b-PEG113), where m is varied, and a hemeprotein, myoglobin (Mb) or horse radish peroxidase (HRP), is described. The synthetic diblock copolymer is first functionalized with the heme cofactor and subsequently reconstituted with the apoprotein or ...
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A series of triblock protein copolymers composed of a central water-soluble polyelectrolyte segment flanked by two coiled-coil domains was synthesized by genetic engineering methods. The copolymers self-assembled into reversible hydrogels in response to changes in temperature, pH, and the presence or absence of denaturating agent (guanidine hydrochloride, GdnHCl). Hydrogel formation was concent...
متن کاملPolypyrrole-incorporated conductive hyaluronic acid hydrogels
BACKGROUND Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. METHOD To create electrically conductive hydrogels, we fabricated composite hyd...
متن کاملHyaluronic acid hydrogels for biomedical applications.
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many physical forms-viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non-woven meshes, macroporous and fibrillar sponges, flexible...
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ژورنال
عنوان ژورنال: Journal of Polymer Science
سال: 2020
ISSN: 2642-4150,2642-4169
DOI: 10.1002/pol.20200081